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Endocrinologia/Glândulas

Associação de anticorpos circulantes e auto-imunidade de tireóide

13/04/2006

Associação de anticorpos circulantes contra a hélice simples e dupla do DNA e Auto-anticorpos da tireóide na doença de Graves e pacientes com tireoidite de Hashimoto

 

Neste estudo foi concluído que a predisposição para o desenvolvimento de doenças auto-imunes sistêmicas não é influenciada por hormônios da tireóide. A alta prevalência de anti-dsDNA e de anti-ssDNA séricos em pacientes portadores de doenças tireoidianas auto-imunes alerta sobre o risco de desenvolvimento de outras doenças auto-imunes sistêmicas.

 

 

Short Communication

Exp Clin Endocrinol Diabetes 2006; 114: 35-38
DOI: 10.1055/s-2005-873005

 


Association of Circulating Antibodies Against Double-Stranded and Single-Stranded DNA with Thyroid Autoantibodies in Graves' Disease and Hashimoto's Thyroiditis Patients[1]

 

A. B. P. Pedro1, J. H. Romaldini1, C. Americo1, K. Takei1

1 Department of Endocrinology & Clinical Laboratory, Hospital do Servidor Público Estadual, IAMSPE, São Paulo, Brazil

Abstract

The occurrence of antinuclear antibody (ANA), rheumatoid factor (RF), antibodies to double-stranded DNA (anti-dsDNA) and to single-stranded DNA (anti-ssDNA) was investigated in 51 patients with autoimmune thyroid diseases (AITD), and in 25 matched control subjects. In comparison with controls, the prevalence of anti-dsDNA was 74.5 % in AITD patients (p = 0.0001), 82.0 % in 39 hyperthyroid Graves' disease (GD) (p = 0.0001), and 50.0 % in 12 euthyroid Hashimoto's thyroiditis (HT) patients (p = 0.0001). The prevalence of anti-ssDNA was 90.1 % in AITD (94.8 % in GD and 75 % in HT; p = 0.001). The concentration of both anti-dsDNA and anti-ssDNA were higher (p = 0.002) in AITD, in GD (p = 0.001), and in HT (p = 0.01) patients than in controls. Two patients with AITD were identified as positive for ANA. RF was detected in 4 AITD patients. Positive correlation was noted between anti-dsDNA with T4 (p = 0.001), T3 (p = 0.002), thyroid peroxidase antibody (anti-TPO) (p = 0.0001), and TSH (p = 0.001) values but not with thyroglobulin antibody (anti-Tg). Serum anti-ssDNA values were also correlated with T3 (p = 0.0001), TSH (p = 0.003), and anti-TPO (p = 0.0001). However, by using a multiple regression analysis only anti-TPO remained associated with anti-dsDNA and both anti-Tg and anti-TPO with anti-ssDNA values. The predisposition to develop systemic autoimmune disorders is not influenced by thyroid hormones. The elevated prevalence of serum anti-dsDNA and anti-ssDNA in AITD patients points out that we must be aware of the risk for predisposition for the development of other systemic autoimmune diseases.

Key words

Antinuclear antibodies - Graves' disease - Hashimoto's thyroiditis - thyroid autoantibodies


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