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Gastroenterologia/Proctologia/Fígado

Tacrolimus é bem tolerado e efetivo na Doença de Crohn refratária

05/11/2008

Leia no artigo abaixo sobre a eficácia e tolerância do Tacrolimus no tratamento da doença de Crohn refratária aos tratamentos convencionais.

 

J Gastroenterol. 2008;43(10):774-9. Epub 2008 Oct 29.


The effect of tacrolimus (FK-506) on Japanese patients with refractory Crohn's disease.

Tamaki H, Nakase H, Matsuura M, Inoue S, Mikami S, Ueno S, Uza N, Kitamura H, Kasahara K, Chiba T.

Department of Gastroenterology & Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawara, Shogoin, Sakyo-ku, Kyoto, 606-8507, Japan.

BACKGROUND: Recent evidence indicates that intravenous or oral therapy with tacrolimus (FK-506) is effective in treating patients with Crohn's disease. We evaluated the usefulness of tacrolimus therapy for Japanese patients with refractory Crohn's disease. METHODS: Fourteen adult Japanese patients with Crohn's disease that was refractory to conventional therapies, including prednisolone (n = 5), azathioprine (n = 6), and infliximab (n = 5), were enrolled. Treatment with tacrolimus was started orally or intravenously and aimed for serum trough levels of 10-15 ng/ml. After the patients achieved clinical improvement, tacrolimus maintenance therapy was administered to maintain the trough level at 5-10 ng/ml. RESULTS: All patients achieved remission or significant improvement 40 days after starting tacrolimus treatment. By 120 days after the start of therapy, 9 (64%) patients achieved remission, 2 patients (14%) achieved significant improvement, and only 3 patients (21%) relapsed. The relapsed patients were treated with infliximab therapy and achieved remission. Steroids were discontinued by the 5 patients who had taken steroids before the study began. Adverse effects of tacrolimus included a temporary increase in serum creatinine concentration (n = 1, 7%), hyperkalemia (n = 1, 7%), and tremor (n = 1, 7%). CONCLUSIONS: Tacrolimus therapy is effective and well tolerated in patients with Crohn's disease that is refractory to conventional therapies.

PMID: 18958546 [PubMed - in process]

 

http://www.ncbi.nlm.nih.gov/pubmed/18958546?dopt=Abstract

 

 

 


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